A Kinder Way to Collect Dolphin DNA

Researchers have found a better and highly resourceful way to get the DNA samples that they need for genetic testing from dolphins and others aquatic animals. Until recently, samples were collected using dart guns from captive and wild dolphins, whales, and porpoises. Recently, researchers have found a more humane way to get the samples they need, replacing the old dart gun methods which are dangerous to the animals and required great skill to avoid injuring the mammals. Additionally, researchers were not able to use this method to extract samples from young or smaller mammals. Now they have begun to capture DNA tissue from the blowhole of the dolphins.

This technique requires the researchers to hold a test tube over the blowhole of the mammal to collect the excretions. Many captive dolphins have even been trained to exhale on cue. Then researchers took blood samples and compared them to the collected blow. The samples were identical and therefore proved that dolphin blow is just as effective as a test sample as the actual blood. This research application has been taken into a wild population in Australia and proven to also be successful in the wild.

Why would a viable and less invasive mode of DNA collection be important for health medicine? One reason is that the dolphin brain is of great interest to human genome researchers because it is the second largest in mass to the human brain based upon body size. Their brains are large and complex with personalities and behaviors that rival that of higher primate species. Scientists have often marveled at the dolphin’s intelligence and unsurpassed intuition when encountering their human counterparts.

The ability to easily collect DNA information from these amazing creatures opens the doors for comparative studies that just might shed light on how the human brain functions and malfunctions which could lead to insights and cures for brain and personality disorders in humans.

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Growing Diversity Good for Genome Studies

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Earlier this year, Africa added two sets of fully sequenced human genomes to the list of donations. The DNA came from a well known civil-rights activist and a tribal hunter-gatherer. These two men live lives and in environments that could not be more different and their samples were different indeed. These samples are important to researchers as they attempt to study where humans originated in Africa and which parts of populations were involved in migrations out of Africa. Scientists want to understand present diversities and track human evolution throughout time and development of diseases.

Some drugs designed to treat Europeans do not respond to the genetic makeup of Africans. This is due to the very diverse genetic patchwork that makes up the country. For example, certain tribes in Africa are more susceptible to Tuberculosis than the rest of the population and are unresponsive to the European drugs. Researchers hope that gathering more genomic data will eventually assist with the development of drugs that will work in these populations. Until this year none of the large human genome projects have been targeted at minority populations despite scientific interest.

Scientists have found the genomes specifically tantalizing as they revealed certain characteristics or adaptations that were most likely environmentally influenced over the course of time. For example one gene is linked to faster sprinting abilities and yet another that helps the kidneys to reabsorb chloride ions; both characteristics would enable a greater chance of survival in the desert environment where they have lived for generations as hunter-gatherers. On the downside, they lack certain genes that would protect them from certain diseases because they were so isolated they never developed them. As the country continues to encroach upon them they are exposed for the first time to illnesses such as malaria.

The few samples that scientists have from Africa only scratch the surface of the information they need to see the whole picture. As the cost of sequencing goes down and genome technology increases they are hopeful that they will be able to sequence a greater number of the diverse African population soon.

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Research Proves Genetic Predisposition to Obesity Can Be Reversed

Biotech researchers in the field of health medicine have discovered that there are certain genetic characteristics that predispose individuals to obesity. Additionally, chemical changes to DNA as a result of environmental and lifestyle factors can also lead to obesity. Human genome researchers usually start by looking for differences and similarities in the DNA of obese individuals versus those of a healthy weight. Despite these results those with genetics not in favor of the skinny jean still have hope and it lies in a virtually free treatment available to all on a global scale.

The health medicine community acknowledges the role that genetics plays in obesity but urges those who are obese not to resign to a fate of being fat simply because of their family history. Studies have been conducted on individual predisposed to obesity to see if the genetics can be overcome by changes in environmental factors and they proved that there is indeed hope for this unwanted inheritance. The studies have indicated that obesity can be reduced by almost fifty percent with increased physical activity. These findings fly in the face of the idea that people are destined to be fat no matter what they may do.

The study also revealed that for those without “fat genes” exercise did not produce as profoundly positive results as it did in those predisposed to obesity. In other words, those who are hard wired to be fatter can get more from exercise than their skinny counterparts.

The next question raised is how much exercise does it really take to trigger a reversal in the fat genes? Various research in multiple countries revealed that the exercise prescription is not a hard pill to swallow. Research suggests that moderate and regular exercise is sufficient. An obese adult who combines a sedentary desk job with 30-60 minutes of physical activity each day can reduce their genetic risk by up to forty percent. Since the benefits of exercise also prevent heart disease and other problems, it looks like the fat genes can be treated with an easy to produce drug-exercise.

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Health Medicine and Types of Cloning

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Completion of the human genome project has caused a huge rise in DNA and genetics research. Increasingly you hear talk of cloning, but what is cloning and what does it mean for the health medicine industry? In today’s biotech community it takes on many meanings. The most commonly discussed type of cloning is reproductive cloning, but there are different types than just reproducing a genetic duplicate of another organism. The three main types of cloning are DNA cloning, reproductive cloning, and therapeutic cloning.

DNA Cloning is also referred to as gene cloning and involves the transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacteria. Then the DNA cell can be reproduced in a different environment. Biotech scientists have been doing this type of cloning since the 1970s but the information obtained as a result of the human genome project have made this practice more common. This type of cloning is important because it provides scientists with data related to gene therapy, sequencing genomes, and genetically engineered organisms.

Reproductive Cloning is creating an animal that has identical DNA to another animal. This is the manner in which Scottish scientist created Dolly the sheep in the late 1990s. The success with Dolly was not complete as it took many tries and expense but as technologies improve, this type of cloning could serve various purposes such as development of drug-producing animals or repopulation of endangered species.

Therapeutic Cloning or embryo cloning is creating human embryos for use in biotech or health medicine research. The goal is harvest stem cells to treat human diseases. Stem cells can recreate specialized cells in humans. Researchers are using the stem cells they gather from produced human embryos to study the treatment of cancer, Alzheimer’s and other diseases. This type of cloning is very controversial in scientific and religious communities.

Much more work by the biotech community will need to take place before these controversial cloning technologies become health medicine realities, but with ever speeding technologies are developed the reality of these ideas draw ever closer.

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The Genetics of Alcoholism

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Scientists are using human genome mapping to search for genetic clues to why certain individuals more likely to suffer the effects of alcoholism. Study of these genes common amongst alcoholics have shown that while alcoholism does appear to run from one generation to the next, not all children of alcoholics are destined to develop alcoholism. Although genetics does play a role, environmental factors also come into play. Identifying the genes that influence the risk for alcoholism and related diseases will lead health medicine researchers to more effective therapies and prevention.

One study conducted by the Collaborative Study of Genetics of Alcoholism (COGA) revealed compelling evidence that the predisposition to alcoholism does pass from one generation to the next genetically. They noted that children with alcoholic parents, especially sons of alcoholic fathers, are four to nine times more likely to suffer from alcoholism that those of nonalcoholic parents; children whose genetic parents were alcoholics but were adopted by nonalcoholic parents were still at a high risk. Meanwhile, those who were raised by alcoholics whose genetic parents were not alcoholics, had a reduced risk of developing problems despite environmental factors.

Scientists began to associate alcoholism and genetics over thirty years ago but have only recently had the research and tools necessary to pinpoint specific genomes in the DNA. Despite these advances, alcoholism is a very complex disease. There are multiple genes interacting with each other and certain environmental and physiological factors that all playing a role. Alcoholism is genetically linked to other addictions and behaviors such as depression, antisocial personality disorders, and nicotine and/or cocaine addiction.

Alcoholism is a bigger problem than one may think, effecting over 75 million people globally. An even greater concern is of those who become dependent and undergo treatment only one-fifth will be sober one year later. The good news is that those who are aware of their genetic predisposition can totally prevent dependence altogether by abstaining from the substance, particularly during their younger years.

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